  Pioneer Glucosamine Chondroitin Joint Care 240 caps
Gluten-Free. MSM: an excellent source of biologically active sulfur. Guaranteed potency, standardized herbal extracts for joint protection: Turmeric, Hawthorn and Gotu Kola. Manganese, boron and trace minerals to support healthy connective tissue and cartilage. High enzyme activity bromelain, used for healing soft tissue injuries. Black Pepper extract to enhance uptake and absorption. Whether due to normal wear and tear, injury, or inherited disposition, degenerative joint disease (osteoarthritis) inhibits freedom of movement in millions of Americans. Even those of us who do not suffer from osteoarthritis may at times experience the discomfort of joint pain and stiffness. The ingredients in PIONEER Glucosamine Chondroitin Joint Care Formula provide joint cartilage and its supportive collagen structure with protective and restorative nourishment, increased circulation and reduced free radical damage. Unlike non-steroidal anti-inflammatory drugs (NSAIDs), which treat only symptoms, Joint Care Formula strives to increase flexibility and mobility while improving the environment of the cartilage and joint overall. Professionally formulated to provide comprehensive support for joint and cartilage health, Pioneer Joint Care Formula provides effective levels of scientifically proven ingredients: glucosamine and chondroitin sulfates, MSM, trace minerals, high activity bromelain & guaranteed potency herbal extracts. Degenerative joint disease (osteoarthritis) damages or destroys cartilage and its supportive collagen structure. As many as 40 million Americans, including the majority of people over age fifty, are thought to suffer from some form of this disease. Primary osteoarthritis, the “wear and tear” form, is due to normal use and age-related causes. Secondary osteoarthritis results from repeated joint trauma, inherited predisposition, or previous inflammatory conditions.While non-steroidal anti-inflammatory drugs (NSAIDs)treat symptoms only, a natural, holistic approach strives to improve the environment of the cartilage and joint as a whole by providing protective and restorative nourishment, increased circulation, decreased inflammation and reduced free radical damage. The ingredients in Pioneer Glucosamine Chondroitin Joint Care Formula are selected to help support this “whole-joint” approach. CONSIDER THESE ADVANTAGES: 1. High Levels of Glucosamine and Chondroitin Sulfate. Widely regarded as the first defense in protecting joints, glucosamine and chondroitin have been shown to effectively control joint pain and slow down or reverse the progression of cartilage deterioration. The integrity of joint gliding surfaces (as well as the health of tendons, ligaments, joint fluids, skin, bones, heart valves and virtually all structural elements in the body) is dependent upon the proper synthesis and availability of proteoglycans, integral components of joint cartilage. Glucosamine provides two components critical to the synthesis of proteoglycans: hyaluronic acid and glycosaminoglycans (GAGs). Chondroitin sulfate represents an important group of GAGs. It is not a single compound, but rather a class of compounds with different molecular weights that each have specialized functions within the body. Numerous studies have shown that long-term safety, reduction in pain and protection of cartilage with both chondroitin and glucosamine are comparable or superior to results obtained with NSAIDs.1-3 2. MSM. (Methylsulfonylmethane) MSM is a rich source of sulfur, a mineral required for GAG synthesis.4 A preliminary study suggests that MSM may help reduce pain in persons with degenerative arthritis.5 3. Gotu Kola. (Centella asiatica) Known to support collagen synthesis and stimulate GAGs, Gotu Kola has been used for many years in Europe to promote wound healing and blood vessel integrity. It also has been shown to improve circulation in small vessels.6,7 4. Turmeric. (Curcuma longa) This saffron-colored root offers a wide range of benefits. It naturally inhibits the inflammatory COX-2 enzyme, reduces pain and is a potent antioxidant that protects the liver and other cells.8 High antioxidant diets may inhibit joint deterioration.9 5. Hawthorn. (Crataegus oxycantha) Antioxidant Hawthorn has been shown to protect collagen from enzyme destruction and protect blood vessel walls.10 It contains potent OPC free radical scavengers. 6. Bromelain. Derived from pineapple cores, Bromelain is most commonly used for healing soft tissue injuries and inflammation. It contains potent selective proteases (protein-digesting enzymes) and other substances which serve to block destruction of GAGs.11 7. Trace Minerals. Micronutrients play many distinct roles in support of healthy joint connective tissue and joint cartilage matrix.12 PIONEER trace minerals are derived from pure, de-salted sea water. 8. Black Pepper Extract. Bioperine® is a highly concentrated extract (95-98% piperine) of black pepper. Used as a bioavailability enhancer, it has been shown to increase the absorption of vitamins, minerals and herbs.13 9. True Full-Disclosure Labeling. All ingredients, their forms, and ratios are fully disclosed on the label of every PIONEER product. Read the label! These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Other ingredients: gelatin (capsule), cellulose, silica, vegetable magnesium stearate. CONTAINS NO gluten, wheat, yeast, corn, soy, added preservatives, colors or flavors, and no toxic levels of heavy metals. Contains shellfish (glucosamine) and BSE-free bovine (chondroitin) derivatives. NATURAL MANUFACTURING AGENTS ONLY. † * Daily Value (DV) not established AMOUNT PER SERVING %DV Serving Size 4 capsules Manganese (from manganese citrate) . . . . . . 2 mg 100 % Glucosamine (93% from glucosamine sulfate • 2 potassium chloride, 7% from n-acetyl d-glucosamine) . . . . . . 1500 mg * Chondroitin Sulfate (micronized) . . . . . . . . 1000 mg * MSM (methylsulfonylmethane) . . . . . . . 500 mg * Boron (organically bound calcium borogluconate) . . . . . . 2 mg * Bromelain 2400 GDU (from pineapple) . . . . . . . 100 mg * Trace Mineral Complex (full-spectrum evaporated de-salted sea water) . . . . . . 50 mg * Standardized Herbal Extracts: Gotu Kola aerial extract Centella asiatica (total asiaticosides 15mg) . . . . 150 mg * Turmeric root extract Curcuma longa (curcuminoids 95mg) . . . . . 100 mg * Hawthorn leaf & flower extract Crataegus oxycantha (proanthocyanidins 9 -15 mg, vitexin-2-rhamnosides >1.8 mg) . . . . . 100 mg * Black Pepper fruit extract 60:1 Piper nigrum † . . . . . . 2 mg * REFERENCES: 1.McAlindon TE, et al. Glucosamine & chondroitin for treatment of osteoarthritis: a systematic quality assesment and meta-analysis. JAMA 2000 Mar 15;283(11):1669-75; 2. Deal CL, et al, Nutraceuticals as therapeutic agents in osteoarthritis: the role of glucosamine, chondroitin and collagen hydrosylate. Rheum Dis Clin M. Am 1999 May 25;(2):379-95; 3. de los Reyes GC. Glucosamine & chondroitin sulfates in the treatment of osteoarthritis: a survey. Prog Drug Res 2000;55:81-103; 4. Hoffer LJ, et al. Sulfate could mediate the therapeutic effect of glucosamine sulfate.Metabolism 2001 Jul;50(7)767-70; 5. Lawrence RM. Lignusul msm – a double blind study of its use in degererative arthritis. prelim corres., www.msm.com 6. Marquart FX, et al. Triterpenes from centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. Eur J Derm 1999 Jum;9(4):289-96; 7. A Shukla, Asiaticoside - induced elevation of antioxicant levels in healing wounds. Phytother Res 1999 Feb;13(1):50-54; 8. Almada A. Natural cox-2 inhibitors-the future of pain relief. Nutr Sci News 2000 Aug;5:8;338-42; 9.McAlindon TE. Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis? Arth Rheum 1996;39:648-56; 10. Chatterjee SS. In vitro & invivo studies on the cardioprotective action of oligomeric procyanidins in a crataegus extract of leaves & blooms. Arzneimittelforschung 1997 Jul;47(7)821-5; 11. Klein G. Reducing pain by oral enzyme therapy in rheumatic diseases.Wein Med Wochenschr 1999;149(21-22):577-80 12. Camper L. Integrin alpha2beta1 is a receptor for cartilage matrix protein. J Cell Biol 1997 Sept 8;138(5):1159-67; 13. Shoba G, et al. Influence of piperine on the pharamacokinetics of curcumin in animals and human volunteers. Planta Med 1998;64(4)353-356 GLUTEN-FREE • NON-GMO
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